Matrix Modifications Modulate Ophthalmic Drug Delivery From Photo-Cross-Linked Poly(propylene Fumarate)-Based Networks

@article{Haesslein2009MatrixMM,
  title={Matrix Modifications Modulate Ophthalmic Drug Delivery From Photo-Cross-Linked Poly(propylene Fumarate)-Based Networks},
  author={A. Haesslein and M. Hacker and H. Ueda and D. Ammon and R. Borazjani and J. Kunzler and J. C. Salamone and A. Mikos},
  journal={Journal of Biomaterials Science, Polymer Edition},
  year={2009},
  volume={20},
  pages={49 - 69}
}
In this work, different modifications of photo-cross-linked poly(propylene fumarate)/poly(N-vinyl pyrrolidone) (PPF/PNVP) matrices were studied for their effect on the release kinetics of two ophthalmic drugs. The hydrophilicity of solid PPF/PNVP matrices loaded with acetazolamide (AZ) or timolol maleate (TM) was increased by adding various amounts of poly(ethylene glycol) (PEG) or by increasing the amount of N-vinyl pyrrolidone (NVP) in the polymer mixture prior to cross-linking. The in vitro… Expand
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