Matrix Modifications Modulate Ophthalmic Drug Delivery From Photo-Cross-Linked Poly(propylene Fumarate)-Based Networks

  title={Matrix Modifications Modulate Ophthalmic Drug Delivery From Photo-Cross-Linked Poly(propylene Fumarate)-Based Networks},
  author={Andrea Haesslein and Michael C. Hacker and Hidenori Ueda and Daniel M. Ammon and Roya N. Borazjani and J F Kunzler and Joseph C. Salamone and Antonios G. Mikos},
  journal={Journal of Biomaterials Science, Polymer Edition},
  pages={49 - 69}
In this work, different modifications of photo-cross-linked poly(propylene fumarate)/poly(N-vinyl pyrrolidone) (PPF/PNVP) matrices were studied for their effect on the release kinetics of two ophthalmic drugs. The hydrophilicity of solid PPF/PNVP matrices loaded with acetazolamide (AZ) or timolol maleate (TM) was increased by adding various amounts of poly(ethylene glycol) (PEG) or by increasing the amount of N-vinyl pyrrolidone (NVP) in the polymer mixture prior to cross-linking. The in vitro… Expand
Biodegradable fumarate-based drug-delivery systems for ophthalmic applications.
The results indicate the potential of photocrosslinked PPF-based matrices as polymeric carriers for long-term ophthalmic drug delivery with promising ocular biocompatibility of drug-free PPF/PVP matrices. Expand
Photo-crosslinked biodegradable polymer networks for controlled intraocular drug delivery
In this thesis the potential of photo-crosslinked polymer networks for intraocular drug delivery is described. Patients with diseases of the back of the eye would benefit considerably from theExpand
Photo-crosslinked networks prepared from fumaric acid monoethyl ester-functionalized poly(D,L-lactic acid) oligomers and N-vinyl-2-pyrrolidone for the controlled and sustained release of proteins.
By varying the NVP content and macromer molecular weight the degradation behavior and protein release profiles of the prepared networks could be tuned and the more hydrophilic and less densely crosslinked networks released albumin and lysozyme at a faster rate. Expand
Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications.
Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) toExpand
From Membrane to Skin: Aqueous Permeation Control Through Light‐Responsive Amphiphilic Polymer Co‐Networks
The functionalization of amphiphilic polymer co-networks with light-responsive spiropyran and spirooxazine derivatives leads to a new type of light-responsive materials. The material consisting ofExpand
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Novel amphiphilic conetworks (APCN) consisting of thermoresponsive poly(N-isoproplyacrylamide) (PNiPAAm) cross-linked by hydrophobic methacrylate-telechelic polyisobutylene (MA-PIB-MA) wereExpand
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Three-armed biodegradable macromers of well-defined chemical characteristics were prepared from trivalent alcohols with different degrees of ethoxylation and different lengths of oligoester domains to establish a macromer platform for preparation of tissue engineering scaffolds with adjustable chemical and mechanical characteristics. Expand
Anomalous swelling behavior of poly(N-vinylimidazole)-l- poly(tetrahydrofuran) amphiphilic conetwork in water studied by solid-state NMR and positron annihilation lifetime spectroscopy
Poly(N-vinylimidazole) homopolymer (PVIm) and poly(N-vinylimidazole)-l-poly(tetrahydrofuran) (PVIm-l-PTHF), a novel amphiphilic polymer conetwork (APCN), were synthesized to compare their solid stateExpand
Unprecedented scissor effect of macromolecular cross-linkers on the glass transition temperature of poly(N-vinylimidazole), crystallinity suppression of poly(tetrahydrofuran) and molecular mobility by solid state NMR in poly(N-vinylimidazole)-l-poly(tetrahydrofuran) conetworks
Unexpected correlations have been found between structural parameters and glass transition temperatures (Tg) of poly(N-vinylimidazole) (PVIm) and crystallinity of poly(tetrahydrofuran) (PTHF) in aExpand
Alternating ring-opening copolymerization of epoxides with saturated and unsaturated cyclic anhydrides: reduced viscosity poly(propylene fumarate) oligomers for use in cDLP 3D printing
A ring-opening copolymerization of propylene oxide with saturated and unsaturated anhydrides using Mg(BHT)2(THF)2 catalyst followed by an isomerization yields poly(propylene fumarate) (PPF) oligomersExpand


Effect of macromer molecular weight on in vitro ophthalmic drug release from photo-crosslinked matrices.
Overall, the results demonstrate that drug release kinetics from photo-crosslinked PPF/polyNVP matrices is strongly dependent on the M(n) of the PPF macromer. Expand
Microparticles of poly(dl-lactic-co-glycolic acid)/poly(ethylene glycol) blends for controlled drug delivery
Abstract We fabricated microparticles of poly( dl -lactic-co-glycolic acid) (PLGA) 50:50 and poly(ethylene glycol) (PEG) blends with entrapped model drug compounds to investigate the effect of blendExpand
Long-term release of fluocinolone acetonide using biodegradable fumarate-based polymers.
  • A. Haesslein, H. Ueda, +6 authors A. Mikos
  • Chemistry, Medicine
  • Journal of controlled release : official journal of the Controlled Release Society
  • 2006
The results show that photo-crosslinked PPF-based matrices are promising long-term delivery devices for intraocular drug delivery. Expand
New biodegradable networks of poly(N-vinylpyrrolidinone) designed for controlled nonburst degradation in the vitreous body.
The chemical synthesis of the crosslinker molecule is reported on, as well as the preparation and degradation of a series of poly(NVP)-based hydrogels in vitro and in vivo (rabbit eyes) and it is found that these materials indeed displayed excellent biocompatibility in the rabbit eye. Expand
Mechanisms controlling protein release from lipidic implants: effects of PEG addition.
Different mass transport mechanisms govern the release of the drug, co-lyophilisation agent and release modifier out of the lipidic implants, irrespective of the amount of added PEG. Expand
A melt-extrusion process for manufacturing matrix drug delivery systems
Abstract A novel melt-extrusion process was developed to prepare matrix drug delivery systems. The disks contained drugs suspended in various polymers or polymer/additive combinations. TheophyllineExpand
PEG modulated release of etanidazole from implantable PLGA/PDLA discs.
In this work, etanidazole is encapsulated into spray dried poly(D),L-lactide-co-glycolide) microspheres and then compressed into discs for controlled release applications and the incorporation of polyethylene glycol (PEG) can greatly enhance the release rate of discs and also reduces the secondary burst effect, thereby achieving a sustained release for about 2 months. Expand
Handbook of Pharmaceutical Controlled Release Technology
Polymers as Drug Delivery Carriers Hydrophilic Cellulose Derivatives as Drug Delivery Carriers: Influence of Substitution Type on the Properties of Compressed Matrix Tablets, Carmen FerreroExpand
Biodegradable Polymers for Ocular Drug Delivery
The fundamental mechanisms of drug delivery systems, polymer erosion and drug release are described, and those systems using the most popular biodegradable polymers, poly(lactic acid) and poly( lactic-glycolic acid), are reviewed. Expand
Kinetics of poly(propylene fumarate) synthesis by step polymerization of diethyl fumarate and propylene glycol using zinc chloride as a catalyst
This study demonstrated that the maximum Mn ofPPF by a transesterification reaction is limited due to gelation of PPF at high temperature. Expand