Matrix Metalloproteinases in Myocardial Infarction and Heart Failure.

  title={Matrix Metalloproteinases in Myocardial Infarction and Heart Failure.},
  author={Kristine Y. DeLeon-Pennell and C{\'e}sar Arruda Meschiari and Mira Jung and Merry L Lindsey},
  journal={Progress in molecular biology and translational science},
Cardiovascular disease is the leading cause of death, accounting for 600,000 deaths each year in the United States. In addition, heart failure accounts for 37% of health care spending. Matrix metalloproteinases (MMPs) increase after myocardial infarction (MI) and correlate with left ventricular dysfunction in heart failure patients. MMPs regulate the remodeling process by facilitating extracellular matrix turnover and inflammatory signaling. Due to the critical role MMPs play during cardiac… CONTINUE READING
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