Corpus ID: 43125853

Matrix Metalloproteinases ( MMPs ) in Oral Squamous Cell Carcinoma

@inproceedings{Bhakhar2017MatrixM,
  title={Matrix Metalloproteinases ( MMPs ) in Oral Squamous Cell Carcinoma},
  author={Dr. Vikas Bhakhar and Dr. Neeta. V. Bhavsar},
  year={2017}
}
Tumor growth and development involves interaction between tumor cells and extracellular matrix components characterized by cell proliferation, survival, migration into other tissues by invasion or metastasis. Migration of these tumor cells involve degradation of ECM which is facilitated by matrix metalloproteinases (MMPs). Thus MMPs serve useful tool for early diagnosis, prognosis and survival of the disease. Active role of various MMPs in oral squamous cell carcinoma have been evaluated by… Expand

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References

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TLDR
The role of MMP-9 is complicated and may fluctuate throughout the different types and stages of oral cancers, and contrary to earlier models, recent studies show that MMPs plays a protective role in oral cancers. Expand
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Serum and plasma levels of MMP and TIMP might be useful in diagnostics and follow-up, however, their use as therapeutic target should be further investigated, since the antitumor activity of matrix metalloproteinase inhibitors has been investigated. Expand
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