Matrix Metalloproteinases: Pathways of Induction by Bioactive Molecules

Abstract

Regulation of the extracellular matrix (ECM) is an important therapeutic target that can potentially attenuate the adverse ventricular remodeling seen in the progression of heart failure. Matrix metalloproteinases (MMPs) degrade numerous ECM proteins. Importantly, the activation of MMPs and their endogenous inhibitors (TIMPs) are associated with ventricular… (More)
DOI: 10.1023/B:HREV.0000011394.34355.bb

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3 Figures and Tables