Matrix Metalloproteinase Inhibitors: Applications in Oncology

@article{Yip1999MatrixMI,
  title={Matrix Metalloproteinase Inhibitors: Applications in Oncology},
  author={Desmond Teck Wing Yip and Athar L. Ahmad and Christos S Karapetis and Carolyn A. Hawkins and Peter G Harper},
  journal={Investigational New Drugs},
  year={1999},
  volume={17},
  pages={387-399}
}
Matrix metalloproteinases (MMP) are a group of zinc dependentenzymes which include the interstitial collagenases, stromelysins,gelatinases and membrane-type metalloproteinases. They are involvedin the remodelling and turnover of the extracellular matrixproteins. They play a role in wound healing and the pathogenesis ofarthritis. In malignancies they play a role in tumor invasion,metastasis and angiogenesis. A number of synthetic matrixmetalloproteinase inhibitors (MMPIs) have been developed… CONTINUE READING
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