Matrix Metalloproteinase Enhances Big-Endothelin-1 Constriction in Mesenteric Vessels of Pregnant Rats With Reduced Uterine Blood Flow1

  • Published 2014


Preeclampsia is a leading cause of maternal and fetal morbidity/ mortality; however, the pathophysiological mechanisms are poorly understood. Vascular endothelial dysfunction in preeclampsia has been partially attributed to changes in endothelin-1 (ET-1). Several enzymes, including matrix metalloproteinases (MMPs, particularly MMP-2), cleave the inactive… (More)