Matrix Metalloproteinase Activity in Pediatric Acute Lung Injury

@article{Kong2009MatrixMA,
  title={Matrix Metalloproteinase Activity in Pediatric Acute Lung Injury},
  author={Michele Y. F. Kong and Amit Gaggar and Yao Li and Margaret K Winkler and J Edwin Blalock and J P Clancy},
  journal={International Journal of Medical Sciences},
  year={2009},
  volume={6},
  pages={9 - 17}
}
Pediatric Acute Lung Injury (ALI) is associated with a high mortality and morbidity, and dysregulation of matrix metalloproteinases (MMPs) may play an important role in the pathogenesis and evolution of ALI. Here we examined MMP expression and activity in pediatric ALI compared with controls. MMP-8, -9, and to a lesser extent, MMP-2, -3, -11 and -12 were identified at higher levels in lung secretions of pediatric ALI patients compared with controls. Tissue Inhibitor of Matrix metalloproteinase… CONTINUE READING

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