Matrix Metalloproteinase-2 and −9 Involvement in Canine Tumors

  title={Matrix Metalloproteinase-2 and −9 Involvement in Canine Tumors},
  author={Panayiotis Loukopoulos and Bruce A Mungall and Rod C Straw and John R. Thornton and Wayne F. Robinson},
  journal={Veterinary Pathology},
  pages={382 - 394}
Matrix metalloproteinases (MMPs) are a family of enzymes implicated in the degradation and remodeling of extracellular matrix and in vascularization. They are also involved in pathologic processes such as tumor invasion and metastasis in experimental cancer models and in human malignancies. We used gelatin zymography and immunohistochemistry to determine whether MMP-2 and MMP-9 are present in canine tumors and normal tissues and whether MMP production correlates with clinicopathologic… 

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