Matrix Metalloproteinase-2 and −9 Involvement in Canine Tumors

@article{Loukopoulos2003MatrixMA,
  title={Matrix Metalloproteinase-2 and −9 Involvement in Canine Tumors},
  author={Panayiotis Loukopoulos and Bruce A Mungall and Rod C Straw and John R. Thornton and Wayne F. Robinson},
  journal={Veterinary Pathology},
  year={2003},
  volume={40},
  pages={382 - 394}
}
Matrix metalloproteinases (MMPs) are a family of enzymes implicated in the degradation and remodeling of extracellular matrix and in vascularization. They are also involved in pathologic processes such as tumor invasion and metastasis in experimental cancer models and in human malignancies. We used gelatin zymography and immunohistochemistry to determine whether MMP-2 and MMP-9 are present in canine tumors and normal tissues and whether MMP production correlates with clinicopathologic… Expand
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MATRIX METALLOPROTEINASE-9 ( MMP-9 ) ACTIVITY IN URINE SAMPLES OF DOGS AFFECTED WITH MAMMARY TUMOR
Matrix metalloproteinases (MMPs) are a large group of proteases activated by Zn 2+ metal ion. A positive correlation between MMP-9 expression and high grade breast carcinoma was reported. CancerExpand
Matrix metalloproteinases 2 and 9 expression in canine normal prostate and with proliferative disorders
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MMP-2 and MMP-9 expression has a variation in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in those with PIA, PIN and PC. Expand
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