Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells.

@article{Bostrm2004MatrixGP,
  title={Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells.},
  author={Kristina I. Bostr{\"o}m and Amina F. Zebboudj and Yucheng Yao and Than S Lin and Alejandra Torres},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 51},
  pages={52904-13}
}
Matrix GLA protein (MGP) is expressed in endothelial cells (EC), and MGP deficiency results in developmental defects suggesting involvement in EC function. To determine the role of MGP in EC, we cultured bovine aortic EC with increasing concentrations of human MGP (hMGP) for 24 h. The results showed increased proliferation, migration, tube formation, and increased release of vascular endothelial growth factor-A (VEGF-A) and basic fibroblast growth factor (bFGF). HMGP, added endogenously or… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

Desphospho-uncarboxylated matrix Gla protein is a novel circulating biomarker predicting deterioration of renal function in the general population

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association • 2018
View 2 Excerpts

Similar Papers

Loading similar papers…