Matrix Elasticity Directs Stem Cell Lineage Specification

@article{Engler2006MatrixED,
  title={Matrix Elasticity Directs Stem Cell Lineage Specification},
  author={Adam J. Engler and Shamik Sen and H. Lee Sweeney and Dennis E. Discher},
  journal={Cell},
  year={2006},
  volume={126},
  pages={677-689}
}

Matrix Elasticity Directs Stem Cell Fates – How Deeply Can Cells Feel?

Naive mesenchymal stem cells from human bone marrow will be shown to specify lineage and commit to phenotypes with extreme sensitivity to tissue level elasticity, which has significant implications for understanding physical effects of the in vivo microenvironment around cells.

Rewiring mesenchymal stem cell lineage specification by switching the biophysical microenvironment

This study demonstrates that MSCs remain susceptible to the biophysical properties of the extracellular matrix—even after several weeks of culture—and can redirect lineage specification in response to changes in the microenvironment.

Matrix Stiffness Modulates Mesenchymal Stem Cell Sensitivity to Geometric Asymmetry Signals

Insight gained from this study provides a rational basis for designing stem cell cultures to enhance tissue engineering and regenerative medicine strategies.

Elongated cell morphology and uniaxial mechanical stretch contribute to physical attributes of niche environment for MSC tenogenic differentiation

It is hypothesize that both enforced elongated cell morphology and uniaxial mechanical stretch signal contribute to the major physical niche attributes of tenocytes' in vivo microenvironment, and mimicking these physical signals may be sufficient to induce tenogenic differentiation of MSCs.

Intrinsic extracellular matrix properties regulate stem cell differentiation.

Extracellular Matrix Regulation of Stem Cell Fate

This review summarizes engineering approaches that have exploited natural and synthetic biomaterials to understand ECM regulation of stem cell fate and demonstrates how these studies have advanced the understanding of vascular maturation and mesenchymal lineage specification.

Regulating osteogenesis and adipogenesis in adipose‐derived stem cells by controlling underlying substrate stiffness

A range of polydimethylsiloxane‐based matrices with differing degrees of stiffness were generated and a comprehensive understanding of how stem cells respond to the surrounding microenvironment was provided, pointing to the fact that matrix stiffness is a critical element in biomaterial design and this will be an important advance in stem cell‐based tissue engineering.

Substrate Stiffness Directs Diverging Vascular Fates.

Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation

A review of a number of recent studies on how cell adhesion and mechanical cues influence the differentiation of MSCs into specific lineages shows evidence that mechanical signals played important roles in regulating a stem cell fate.

Factors Direct the Mesenchymal Stem Cell Lineage Commitment Reproductive Stem Cell Differentiation : Extracellular Matrix , Tissue Microenvironment , and Growth

The mesenchymal stem cells have awakened interest in regenerative medicine due to its high capability to proliferate and differentiate in multiple specialized lineages under defined conditions, and protocols of reproductive MSCs differentiation must be established.
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