Matrix Elasticity Directs Stem Cell Lineage Specification

@article{Engler2006MatrixED,
  title={Matrix Elasticity Directs Stem Cell Lineage Specification},
  author={A. Engler and S. Sen and H. Sweeney and D. Discher},
  journal={Cell},
  year={2006},
  volume={126},
  pages={677-689}
}
  • A. Engler, S. Sen, +1 author D. Discher
  • Published 2006
  • Chemistry, Medicine, Biology
  • Cell
  • Microenvironments appear important in stem cell lineage specification but can be difficult to adequately characterize or control with soft tissues. [...] Key Result During the initial week in culture, reprogramming of these lineages is possible with addition of soluble induction factors, but after several weeks in culture, the cells commit to the lineage specified by matrix elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.Expand Abstract
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    References

    SHOWING 1-10 OF 92 REFERENCES
    Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment.
    • 3,478
    • Highly Influential
    • PDF
    Substrate modulus directs neural stem cell behavior.
    • 871
    • PDF
    Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery
    • 927
    • Highly Influential
    • PDF
    Astrocytic and neuronal fate of mesenchymal stem cells expressing nestin
    • 95
    • Highly Influential
    Tissue Cells Feel and Respond to the Stiffness of Their Substrate
    • 4,892
    • PDF
    Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis
    • 444
    • Highly Influential
    Adhesion-contractile balance in myocyte differentiation
    • 101
    • PDF