Matrix Elasticity Directs Stem Cell Lineage Specification


Microenvironments appear important in stem cell lineage specification but can be difficult to adequately characterize or control with soft tissues. Naive mesenchymal stem cells (MSCs) are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity. Soft matrices that mimic brain are neurogenic, stiffer matrices… (More)
DOI: 10.1016/j.cell.2006.06.044


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