Matrix‐M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model

@inproceedings{Pedersen2011MatrixMAV,
  title={Matrix‐M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model},
  author={Gabriel Kristian Pedersen and Diane L Major and Sarah Roseby and John Wood and A S Madhun and Rebecca Jane Cox},
  booktitle={Influenza and other respiratory viruses},
  year={2011}
}
BACKGROUND A candidate pandemic influenza H5N1 vaccine should provide rapid and long-lasting immunity against antigenically drifted viruses. As H5N1 viruses are poorly immunogenic, this may require a combination of immune potentiating strategies. An attractive approach is combining the intrinsic immunogenicity of virosomes with another promising adjuvant to further boost the immune response. As regulatory authorities have not yet approved a surrogate correlate of protection for H5N1 vaccines… CONTINUE READING

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