Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium.

@article{Beaulieu2013MatriptasePA,
  title={Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium.},
  author={Alexandre Beaulieu and {\'E}milie Gravel and Alexandre Cloutier and Isabelle Marois and {\'E}lo{\"i}c Colombo and Antoine D{\'e}silets and Catherine Verreault and Richard Leduc and {\'E}ric Marsault and Martin V. Richter},
  journal={Journal of virology},
  year={2013},
  volume={87 8},
  pages={4237-51}
}
Influenza viruses do not encode any proteases and must rely on host proteases for the proteolytic activation of their surface hemagglutinin proteins in order to fuse with the infected host cells. Recent progress in the understanding of human proteases responsible for influenza virus hemagglutinin activation has led to the identification of members of the type II transmembrane serine proteases TMPRSS2 and TMPRSS4 and human airway trypsin-like protease; however, none has proved to be the sole… CONTINUE READING
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Matriptase , HAT and TMPRSS 2 activate the hemagglutinin of H 9 N 2 influenza A viruses

  • J Baron, C Tarnow, +9 authors E Bottcher-Friebertshauser
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