Matriptase Deletion Initiates a Sjögren’s Syndrome-Like Disease in Mice

@inproceedings{Yin2014MatriptaseDI,
  title={Matriptase Deletion Initiates a Sj{\"o}gren’s Syndrome-Like Disease in Mice},
  author={Hongen Yin and P J{\'a}nos K{\'o}sa and Xibao Liu and William Swaim and Zhennan Lai and Javier Cabrera-P{\'e}rez and Giovanni Di Pasquale and Indu S Ambudkar and Thomas H Bugge and John A. Chiorini},
  booktitle={PloS one},
  year={2014}
}
OBJECTIVE The objective of this study was to determine the effect of epithelial barrier disruption, caused by deficiency of the membrane-anchored serine protease, matriptase, on salivary gland function and the induction of autoimmunity in an animal model. METHODS Embryonic and acute ablation of matriptase expression in the salivary glands of mice was induced, leading to decreased epithelial barrier function. Mice were characterized for secretory epithelial function and the induction of… CONTINUE READING
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A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming

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