Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis.

  title={Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis.},
  author={Andrew J. Ramsay and John David Hooper and Alicia R. Folgueras and Gloria Velasco and Carlos L{\'o}pez-Ot{\'i}n},
  volume={94 6},
Maintaining the body's levels of iron within precise boundaries is essential for normal physiological function. Alterations of these levels below or above the healthy limit lead to a systemic deficiency or overload in iron. The type-two transmembrane serine protease (TTSP), matriptase-2 (also known as TMPRSS6), is attracting significant amounts of interest due to its recently described role in iron homeostasis. The finding of this regulatory role for matriptase-2 was originally derived from the… CONTINUE READING
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