Matrine suppresses the migration and invasion of NSCLC cells by inhibiting PAX2-induced epithelial-mesenchymal transition

@inproceedings{Yang2017MatrineST,
  title={Matrine suppresses the migration and invasion of NSCLC cells by inhibiting PAX2-induced epithelial-mesenchymal transition},
  author={Jun Yang and Du He and Yan Peng and Hongzhen Zhong and Yuhong Deng and Zhonghua Yu and Chengnong Guan and Yufang Zuo and Zumin Xu},
  booktitle={OncoTargets and therapy},
  year={2017}
}
Non-small cell lung cancer (NSCLC) is the major cause of deaths among all the cancer types worldwide. Most of the NSCLC is diagnosed at an advanced stage and the 5-year overall survival rate is low. The reason for the low survival rate of patients with NSCLC is mainly due to distant metastasis. Matrine, a traditional Chinese medicine, has been shown a significant anti-proliferation and anti-invasive effect in tumors. However, little is known on the anti-invasive mechanism of matrine in lung… CONTINUE READING

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