Matrine inhibits proliferation and induces apoptosis of pancreatic cancer cells in vitro and in vivo.

@article{Liu2010MatrineIP,
  title={Matrine inhibits proliferation and induces apoptosis of pancreatic cancer cells in vitro and in vivo.},
  author={Tianyou Liu and Yan Song and Hua Chen and Shangha Pan and Xueying Sun},
  journal={Biological & pharmaceutical bulletin},
  year={2010},
  volume={33 10},
  pages={1740-5}
}
Matrine, an alkaloid extracted from a Chinese herb, Sophora flavescens AIT., has exhibited anti-proliferative and pro-apoptotic abilities against various types of cancer cells. This study aims to investigate its anti-cancer activity and underlying mechanisms in human pancreatic cancer cells in vitro and in vivo. Human BxPC-3 and PANC-1 pancreatic cancer cells, and human HL-7702 liver cells were incubated with matrine at different concentrations. Cell viability was assessed by 3-(4,5… CONTINUE READING