Matrine induced gastric cancer MKN45 cells apoptosis via increasing pro-apoptotic molecules of Bcl-2 family.

@article{Luo2007MatrineIG,
  title={Matrine induced gastric cancer MKN45 cells apoptosis via increasing pro-apoptotic molecules of Bcl-2 family.},
  author={Cong Luo and Yongliang Zhu and Tiejun Jiang and Xiaoyong Lu and Wo Zhang and Qifeng Jing and Jia Li and Linrong Pang and Kangjie Chen and Fuming Qiu and Xiuyan Yu and Jiahui Yang and Jian Huang},
  journal={Toxicology},
  year={2007},
  volume={229 3},
  pages={245-52}
}
Matrine, one of the main active components from the dry roots of Sophora flavescence, was known to induce apoptosis in a variety of tumor cells in vitro. However, the molecular mechanism of cell apoptosis induced by Matrine remains elusive. Here, we investigated the apoptosis in Matrine-treated human gastric cancer MKN45 cells. The results showed that Matrine could inhibit cell proliferation and induce apoptosis in a dose-dependent manner. Further immunoblots revealed that in Matrine-treated… CONTINUE READING

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