Matrine derivative WM130 inhibits hepatocellular carcinoma by suppressing EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways.

@article{Qian2015MatrineDW,
  title={Matrine derivative WM130 inhibits hepatocellular carcinoma by suppressing EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways.},
  author={Liqiang Qian and Yan Liu and Yang Xu and Weidan Ji and Qiuye Wu and Yongjing Liu and Quangen Gao and Changqing Su},
  journal={Cancer letters},
  year={2015},
  volume={368 1},
  pages={
          126-134
        }
}
Matrine, a sophora alkaloid, has been demonstrated to exert antitumor effects on many types of cancer. However, its bioactivity is weak and its potential druggability is low. We modified the structure of matrine and obtained a new matrine derivative, WM130 (C30N4H40SO5F), which exhibited better pharmacological activities than matrine. In this study, we investigated the antitumor activity and the underlying mechanisms of WM130 on hepatocellular carcinoma (HCC) cells in vitro and in vivo, and… CONTINUE READING

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