Matrilysins-1 and -2 (MMP-7 and -26) and metalloelastase (MMP-12), unlike MMP-19, are up-regulated in necrotizing enterocolitis.

@article{Bister2005Matrilysins1A,
  title={Matrilysins-1 and -2 (MMP-7 and -26) and metalloelastase (MMP-12), unlike MMP-19, are up-regulated in necrotizing enterocolitis.},
  author={Ville Bister and Mikko Salmela and P{\"a}ivi Heikkil{\"a} and Annaleena Anttila and Risto Rintala and Keichi Isaka and Sture Andersson and Ulpu K Saarialho-Kere},
  journal={Journal of pediatric gastroenterology and nutrition},
  year={2005},
  volume={40 1},
  pages={60-6}
}
OBJECTIVES Necrotizing enterocolitis (NEC) is the most common gastrointestinal disease of premature infants characterized histologically by extensive tissue injury and inflammation. Matrix metalloproteinases (MMP) are involved in tissue remodeling and cell migration, both being important aspects of inflammatory disease. The aim of this study was to investigate whether MMPs play a role in the pathogenesis of NEC. METHODS Expression of MMP-1, -7, -9, -10, -12, -19 and -26 was studied using in… CONTINUE READING

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