Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis.

  title={Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis.},
  author={Barbara Fingleton and Tracy Vargo-Gogola and Howard C. Crawford and Lynn M Matrisian},
  volume={3 6},
The matrix metalloproteinase matrilysin (MMP-7) has been demonstrated to contribute to tumor development. We have shown previously that members of the TNF family of apoptosis-inducing proteins are substrates for this enzyme, resulting in increased death pathway signaling. The goal of the current study was to reconcile the proapoptotic and tumor-promoting functions of matrilysin. In the human HBL100 and murine NMuMG cell lines that represent early stages of tumor progression and that express… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 72 extracted citations

Immunomodulatory Activity of VEGF in Cancer.

International review of cell and molecular biology • 2017
View 2 Excerpts

Matrix metalloproteases expression in different histological types of colorectal polyps.

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva • 2017

Similar Papers

Loading similar papers…