Matrigel supports survival and neuronal differentiation of grafted embryonic stem cell-derived neural precursor cells.

@article{Uemura2010MatrigelSS,
  title={Matrigel supports survival and neuronal differentiation of grafted embryonic stem cell-derived neural precursor cells.},
  author={Makoto Uemura and Mohamed M. Refaat and Mizuya Shinoyama and Hideki Hayashi and N. Hashimoto and Jun Takahashi},
  journal={Journal of neuroscience research},
  year={2010},
  volume={88 3},
  pages={542-51}
}
Cell replacement therapy holds great promise as a means of treating neurological disorders, including Parkinson's disease. However, one of the major obstacles to the success of this treatment is the low survival rate of grafted cells, which probably results from mechanical damage, acute inflammation, and immunological rejection. To overcome this problem, we investigated the effect of different types of extracellular matrix (ECM) on the survival and differentiation of embryonic stem (ES) cell… CONTINUE READING
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