Matricryptins Network with Matricellular Receptors at the Surface of Endothelial and Tumor Cells

@inproceedings{RicardBlum2016MatricryptinsNW,
  title={Matricryptins Network with Matricellular Receptors at the Surface of Endothelial and Tumor Cells},
  author={Sylvie Ricard-Blum and Sylvain D. Vallet},
  booktitle={Front. Pharmacol.},
  year={2016}
}
The extracellular matrix (ECM) is a source of bioactive fragments called matricryptins or matrikines resulting from the proteolytic cleavage of extracellular proteins (e.g., collagens, elastin, and laminins) and proteoglycans (e.g., perlecan). Matrix metalloproteinases (MMPs), cathepsins, and bone-morphogenetic protein-1 release fragments, which regulate physiopathological processes including tumor growth, metastasis, and angiogenesis, a pre-requisite for tumor growth. A number of matricryptins… CONTINUE READING
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