Matricellular proteins in cardiac adaptation and disease.

@article{Frangogiannis2012MatricellularPI,
  title={Matricellular proteins in cardiac adaptation and disease.},
  author={Nikolaos G Frangogiannis},
  journal={Physiological reviews},
  year={2012},
  volume={92 2},
  pages={
          635-88
        }
}
The term matricellular proteins describes a family of structurally unrelated extracellular macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue architecture, but are induced following injury and modulate cell-cell and cell-matrix interactions. When released to the matrix, matricellular proteins associate with growth factors, cytokines, and other bioactive effectors and bind to cell surface receptors transducing signaling cascades. Matricellular proteins… CONTINUE READING

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