Matricellular proteins: new molecular targets to prevent heart failure.

  title={Matricellular proteins: new molecular targets to prevent heart failure.},
  author={Hiroshi Okamoto and Kyoko Imanaka-Yoshida},
  journal={Cardiovascular therapeutics},
  volume={30 4},
Matricellular proteins are highly expressed in reparative responses to pressure and volume overload, ischemia, oxidative stress after myocardial injury, and modulate the inflammatory and fibrotic process in ventricular remodeling, which leads to cardiac dysfunction and eventually overt heart failure. Generally, matricellular proteins loosen strong adhesion of cardiomyocytes to extracellular matrix, which would help cells to move for rearrangement and allow inflammatory cells and capillary… CONTINUE READING