Mating-type genes and MAT switching in Saccharomyces cerevisiae.

  title={Mating-type genes and MAT switching in Saccharomyces cerevisiae.},
  author={James E Haber},
  volume={191 1},
Mating type in Saccharomyces cerevisiae is determined by two nonhomologous alleles, MATa and MATα. These sequences encode regulators of the two different haploid mating types and of the diploids formed by their conjugation. Analysis of the MATa1, MATα1, and MATα2 alleles provided one of the earliest models of cell-type specification by transcriptional activators and repressors. Remarkably, homothallic yeast cells can switch their mating type as often as every generation by a highly… CONTINUE READING