Mathematical simulations of ligand-gated and cell-type specific effects on the action potential of human atrium.

@article{Maleckar2008MathematicalSO,
  title={Mathematical simulations of ligand-gated and cell-type specific effects on the action potential of human atrium.},
  author={Mary M. Maleckar and Joseph L. Greenstein and Natalia A. Trayanova and Wayne R Giles},
  journal={Progress in biophysics and molecular biology},
  year={2008},
  volume={98 2-3},
  pages={161-70}
}
In the mammalian heart, myocytes and fibroblasts can communicate via gap junction, or connexin-mediated current flow. Some of the effects of this electrotonic coupling on the action potential waveform of the human ventricular myocyte have been analyzed in detail. The present study employs a recently developed mathematical model of the human atrial myocyte to investigate the consequences of this heterogeneous cell-cell interaction on the action potential of the human atrium. Two independent… CONTINUE READING
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