Mathematical prediction of drug distributionin vivo: Studies with doxantrazole in rats

Abstract

A pharmacokinetic model incorporating 14 compartments and 29 transfer coefficients has been developed from experimental data obtained after intravenous administration of a single dose to describe the distribution of doxantrazole in the rat. The distribution calculated from the model agreed closely with that determined experimentally. In addition, the model… (More)
DOI: 10.1007/BF01062107

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@article{Caldwell1978MathematicalPO, title={Mathematical prediction of drug distributionin vivo: Studies with doxantrazole in rats}, author={Ian C. Caldwell and Saiyed Mahmood and Miles Weatherall}, journal={Journal of Pharmacokinetics and Biopharmaceutics}, year={1978}, volume={6}, pages={521-537} }