Mathematical optimization applications in metabolic networks.

  title={Mathematical optimization applications in metabolic networks.},
  author={Ali R. Zomorrodi and Patrick F. Suthers and Sridhar Ranganathan and Costas D. Maranas},
  journal={Metabolic engineering},
  volume={14 6},
Genome-scale metabolic models are increasingly becoming available for a variety of microorganisms. This has spurred the development of a wide array of computational tools, and in particular, mathematical optimization approaches, to assist in fundamental metabolic network analyses and redesign efforts. This review highlights a number of optimization-based frameworks developed towards addressing challenges in the analysis and engineering of metabolic networks. In particular, three major types of… CONTINUE READING