Mathematical models to describe iontophoretic transport in vitro and in vivo and the effect of current application on the skin barrier.

@article{Gratieri2013MathematicalMT,
  title={Mathematical models to describe iontophoretic transport in vitro and in vivo and the effect of current application on the skin barrier.},
  author={Tais Gratieri and Yogeshvar N Kalia},
  journal={Advanced drug delivery reviews},
  year={2013},
  volume={65 2},
  pages={315-29}
}
The architecture and composition of the stratum corneum make it a particularly effective barrier against the topical and transdermal delivery of hydrophilic molecules and ions. As a result, different strategies have been explored in order to expand the range of therapeutic agents that can be administered by this route. Iontophoresis involves the application of a small electric potential to increase transport into and across the skin. Since current flow is preferentially via transport pathways… CONTINUE READING
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