Mathematical models of RNA silencing: unidirectional amplification limits accidental self-directed reactions.

@article{Bergstrom2003MathematicalMO,
  title={Mathematical models of RNA silencing: unidirectional amplification limits accidental self-directed reactions.},
  author={Carl T. Bergstrom and E. J. McKittrick and Rustom Antia},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 20},
  pages={11511-6}
}
RNA silencing, found broadly throughout the eukaryotes, posttranscriptionally suppresses the expression of "aberrant" genes including those of many viruses and transposons. Similar to the specific immune system of vertebrates, RNA silencing works by generating specific responses against foreign elements and rapidly amplifying these responses to clear or otherwise inactivate the threat. Also like the vertebrate immune system, RNA-silencing systems risk making mistakes and mounting undesirable… CONTINUE READING