Mathematical modelling of tumour acidity: regulation of intracellular pH.

@article{Webb1999MathematicalMO,
  title={Mathematical modelling of tumour acidity: regulation of intracellular pH.},
  author={S. D. Webb and Jonathan A. Sherratt and Reginald G. Fish},
  journal={Journal of theoretical biology},
  year={1999},
  volume={196 2},
  pages={237-50}
}
Measurements of extracellular pH (pHe) in vivo have shown that the microenvironment in tumours is more acidic than in normal tissue. However, both human and animal tumour cells have been shown to have an intracellular pH (pHi) on the alkaline side of neutrality (pH 7.1-7.2). This gives rise to a reversed pH gradient between tumours and normal tissue which implies that cells within solid tumours are capable of maintaining their level of pHi at physiological levels, despite lower than normal… CONTINUE READING