Mathematical modelling of the citric acid cycle for the analysis of glutamine isotopomers from cerebellar astrocytes incubated with [1(-13)C]glucose.

@article{Merle1996MathematicalMO,
  title={Mathematical modelling of the citric acid cycle for the analysis of glutamine isotopomers from cerebellar astrocytes incubated with [1(-13)C]glucose.},
  author={Michel Merle and Miguel Mart{\'i}n and A Vill{\'e}gier and Paul Canioni},
  journal={European journal of biochemistry},
  year={1996},
  volume={239 3},
  pages={742-51}
}
A mathematical model of the citric acid cycle devoted to the analysis of 13C-NMR data was developed for determining the relative flux of molecules through the anaplerotic versus oxidative pathways and the relative pyruvate carboxylase versus pyruvate dehydrogenase activities. Different variants of the model were considered depending on the reversibility of the conversion of fumarate into malate and oxaloacetate. The model also included the possibility of orientation-conserved transfer of the… CONTINUE READING