Mathematical modelling of the chemotherapy of Plasmodium falciparum malaria with artesunate: postulation of 'dormancy', a partial cytostatic effect of the drug, and its implication for treatment regimens.

@article{Hoshen2000MathematicalMO,
  title={Mathematical modelling of the chemotherapy of Plasmodium falciparum malaria with artesunate: postulation of 'dormancy', a partial cytostatic effect of the drug, and its implication for treatment regimens.},
  author={Moshe B Hoshen and Kesara Na-Bangchang and Wilfred Donald Stein and Haga{\"i} Ginsburg},
  journal={Parasitology},
  year={2000},
  volume={121 ( Pt 3)},
  pages={237-46}
}
Although artesunate, one of the potent derivatives of the qinghaosu family of drugs for treating falciparum malaria, is already in use in the field, its therapeutic protocol has only been developed empirically by hit-or-miss. A pharmacokinetic-pharmacodynamic (PK-PD) model, required for creating such a protocol, is not straightforward. Artesunate presents extremely fast pharmacokinetics. As a result the stage specificity of its action must be treated explicitly. Also, use of standard PK-PD… CONTINUE READING
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