Mathematical modelling of microenvironment and growth in EMT6/Ro multicellular tumour spheroids.

@article{Casciari1992MathematicalMO,
  title={Mathematical modelling of microenvironment and growth in EMT6/Ro multicellular tumour spheroids.},
  author={Joseph J. Casciari and Stratis V. Sotirchos and Robert M. Sutherland},
  journal={Cell proliferation},
  year={1992},
  volume={25 1},
  pages={1-22}
}
In order to determine the role of micromilieu in tumour spheroid growth, a mathematical model was developed to predict EMT6/Ro spheroid growth and microenvironment based upon numerical solution of the diffusion/reaction equation for oxygen, glucose, lactate ion, carbon dioxide, bicarbonate ion, chlorine ion and hydrogen ion along with the equation of electroneutrality. This model takes into account the effects of oxygen concentration, glucose concentration and extracellular pH on cell growth… CONTINUE READING
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