Mathematical modelling of HCV infection: what can it teach us in the era of direct-acting antiviral agents?

@article{Chatterjee2012MathematicalMO,
  title={Mathematical modelling of HCV infection: what can it teach us in the era of direct-acting antiviral agents?},
  author={Anushree Chatterjee and J{\'e}r{\'e}mie Guedj and Alan S. Perelson},
  journal={Antiviral therapy},
  year={2012},
  volume={17 6 Pt B},
  pages={1171-82}
}
HCV infection is a major cause of chronic liver disease and affects nearly 170 million people worldwide. Whereas the previous standard of care with pegylated interferon and ribavirin had a modest effectiveness, the recent approval of two highly potent protease inhibitors and the ongoing development of dozens of direct-acting antiviral agents (DAAs) constitute a major milestone for HCV therapy. Mathematical modelling of viral kinetics under treatment has played an instrumental role in improving… CONTINUE READING
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