Mathematical modeling strategies for the analysis of epidemiologic research.

  title={Mathematical modeling strategies for the analysis of epidemiologic research.},
  author={R. Greenberg and D. Kleinbaum},
  journal={Annual review of public health},
In the inaugural volume of the Annual Review of Public Health, Reuel Stallones suggested the following central axiom of epidemiology (27): "Disease does not distribute randomly in human populations." As a corollary to this axiom, Professor Stallones stated: "Variations in the frequency of human disease occur in response to variations in the intensity of exposure to etiologic agents or other more remote causes, or to variations in the susceptibility of individuals to the operation of these… Expand
Assessing the effect of time-varying covariates in cross-sectional studies.
Transfer exposure change rates of healthy subjects to diseased subjects is suggested as an ad hoc method for assessing the hypothetical current relationship between exposure and disease. Expand
The path analysis approach for the multivariate analysis of infant mortality data.
PA allows investigation of more complex models, providing information that could have been previously overlooked, such as how the interrelations among independent variables in a model affect the dependent ones. Expand
Modeling biocultural interactions: Examples from studies of stress and cardiovascular disease
Anthropology, as a unified science of human existence, seeks to understand a variety of influences and outcomes in the process of human adaptation. In that there is a complex interaction betweenExpand
Comparing Sample Surveys of Health with Official Population Statistics: Some Methodological Issues and Empirical Findings
This article reports an examination of factors that might affect the interpretation of computed relative risks of medical illness obtained when estimates of morbidity derived from a specificExpand
Estimating health risks from natural hazards using risk assessment and epidemiology.
This work modified the risk assessment paradigm to address mitigation, the equivalent of risk management, and illustrates that prevention effectiveness is useful for developing cost-effective risk management options. Expand
Gene-environment interactions in cardiovascular disease
  • E. Flowers, E. Froelicher, B. Aouizerat
  • Medicine
  • European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology
  • 2012
Theoretical underpinnings of gene–environment interactions, models of interaction, methods for studying gene– Environment interactions, and the related concept of interactions between epigenetic mechanisms and the environment are described. Expand
Teaching Statistical Principles Using Epidemiology
Recent developments in education have addressed the need to expand and enhance the teaching of statistics and mathematics throughout education (K–16) to improve the statistical literacy andExpand
[Air pollutant burden and bronchial asthma in school children].
Only one of the four hypothesis variables displays a significant effect on the prevalence of asthma: Stoves as heating device carry a 4.8-fold relative risk for asthma compared to other types of heating. Expand
Drinking water contamination and the incidence of leukemia: an ecologic study.
The observed association appears to suggest that drinking water contaminated with VOCs may increase the incidence of leukemia among exposed females, but caution is advised in the interpretation of these results because of the uncertainties inherent in ecologic studies. Expand
Water nitrates and CNS birth defects: a population-based case-control study.
The study revealed that the effect of nitrate exposure in water was modified by whether the source of the drinking water was a private well or a public municipal distribution system, which resulted in a positive increase in risk of delivering a CNS-malformed infant. Expand


A multivariate analysis of the risk of coronary heart disease in Framingham.
It is shown that study populations of this size are not often available and one is consequently led to seek a more powerful form of analysis than inspection of the results of a multiple cross-classification. Expand
Concepts of interaction.
It is proposed that synergy (or its negative counterpart, antagonism) between two or more causes of disease ought to be evaluated in reference to a specific yardstick, with effect defined as excess risk. Expand
Appropriate uses of multivariate analysis.
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  • Computer Science, Medicine
  • Annual review of public health
  • 1983
Comparison of the articles in today's biomedical literature with those of twenty years ago reveals many changes. In particular, there seem to have been large increases over time in three indices: theExpand
The Health Opinion Survey: Technique for Estimating Prevalence of Psychoneurotic and Related Types of Disorder in Communities
This paper presents the results of an attempt to devise and standardize a psychological screening test for adults in rural communities. The need for such a rest arose in connection with a largerExpand
Are there two logistic regressions for retrospective studies?
A comparison is made between two different approaches to the linear logistic regression analysis of retrospective study data: the prospective model wherein the dependent variable is a dichotomousExpand
Multiple testing of hypotheses in comparing two groups.
Three multivariate procedures are described: Hotelling's T2, discriminant analysis, and logistic regression; the underlying assumptions and relative merits and disadvantages are reviewed and which method to use in various circumstances is recommended. Expand
The CES-D Scale
The CES-D scale is a short self-report scale designed to measure depressive symptomatology in the general population. The items of the scale are symptoms associated with depression which have beenExpand
Statis­ tical Methods in Cancer Research, Vol. I , The Analysis of Case-Control Studies. Lyon: IntI
  • Agency for Research on Cancer
  • 1980
Problems of cross validation
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  • 1983
198 1 . Comparison of two modes of stress management : Dai ! y hassles and uplifts versus major life events
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