• Corpus ID: 18928743

Mathematical modeling of type 1 diabetes in the NOD mouse: separating incidence and age of onset

  title={Mathematical modeling of type 1 diabetes in the NOD mouse: separating incidence and age of onset},
  author={James R Moore and Frederico Adler},
  journal={arXiv: Tissues and Organs},
Type 1 diabetes (T1D) is an autoimmune disease of the beta cells of the pancreas. The nonobese diabetic (NOD) mouse is a commonly used animal model, with roughly an 80% incidence rate of T1D among females. In 100% of NOD mice, macrophages and T-cells invade the islets in a process called insulitis. It can be several weeks between insulitis and T1D, and some mice do not progress at all. It is thought that this delay is mediated by regulatory T-cells (Tregs) and that a gradual loss of… 
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