• DOI:10.1016/j.mbs.2016.03.016
Corpus ID: 14593203

Mathematical modeling of perifusion cell culture experiments on GnRH signaling.

@article{Temamogullari2016MathematicalMO,
  title={Mathematical modeling of perifusion cell culture experiments on GnRH signaling.},
  author={N. E. Temamogullari and H. Nijhout and Michael C Reed},
  journal={Mathematical biosciences},
  year={2016},
  volume={276},
  pages={
          121-32
        }
}

• N. E. Temamogullari, H. Nijhout, Michael C Reed
• Published 2016
• Chemistry, Biology, Medicine
• Mathematical biosciences

The effects of pulsatile GnRH stimulation on anterior pituitary cells are studied using perifusion cell cultures, where constantly moving culture medium over the immobilized cells allows intermittent GnRH delivery. The LH content of the outgoing medium serves as a readout of the GnRH signaling pathway activation in the cells. The challenge lies in relating the LH content of the medium leaving the chamber to the cellular processes producing LH secretion. To investigate this relation we developed… Expand

View on PubMed

arxiv.org

Save to Library

Create Alert

Cite

Launch Research Feed