Mathematical modeling of microRNA-mediated mechanisms of translation repression.

@article{Zinovyev2013MathematicalMO,
  title={Mathematical modeling of microRNA-mediated mechanisms of translation repression.},
  author={A. Zinovyev and N. Morozova and Alexander N. Gorban and Annick Harel-Belan},
  journal={Advances in experimental medicine and biology},
  year={2013},
  volume={774},
  pages={
          189-224
        }
}
MicroRNAs can affect the protein translation using nine mechanistically different mechanisms, including repression of initiation and degradation of the transcript. There is a hot debate in the current literature about which mechanism and in which situations has a dominant role in living cells. The worst, same experimental systems dealing with the same pairs of mRNA and miRNA can provide ambiguous evidences about which is the actual mechanism of translation repression observed in the experiment… Expand
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