Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and death.

@article{Remien2012MathematicalMO,
  title={Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and death.},
  author={Christopher H. Remien and Frederick R. Adler and Lindsey Waddoups and Terry D. Box and Norman L Sussman},
  journal={Hepatology},
  year={2012},
  volume={56 2},
  pages={727-34}
}
UNLABELLED Acetaminophen (APAP) is the leading cause of acute liver injury in the developed world. Timely administration of N-acetylcysteine (N-Ac) prevents the progression of serious liver injury and disease, whereas failure to administer N-Ac within a critical time frame allows disease progression and in the most severe cases may result in liver failure or death. In this situation, liver transplantation may be the only life-saving measure. Thus, the outcome of an APAP overdose depends on the… CONTINUE READING