Mathematical modeling of induced foreign protein production by recombinant bacteria.

  title={Mathematical modeling of induced foreign protein production by recombinant bacteria.},
  author={Jason A. Lee and W. Fred Ramirez},
  journal={Biotechnology and bioengineering},
  volume={39 6},
A new generalized mathematical model for recombinant bacteria which includes inducer effects on cell growth and foreign protein production is developed. The model equation set was applied to a host-vector system, Escherichi coli D1210 and plasmid pSD8. Batch experiments were designed and performed in shake flasks to verify the model. A parameter estimation method was developed and proven to be efficient. Although simple, the model can effectively describe the dynamics of the production of… CONTINUE READING

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