Mathematical modeling of drug delivery from torus-shaped single-layer devices.

  title={Mathematical modeling of drug delivery from torus-shaped single-layer devices.},
  author={Ignacio M. Helbling and Julio A. Luna and Mar{\'i}a I. Cabrera},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={149 3},
A mathematical modeling of controlled release of drug from torus-shaped single-layer devices is presented. Analytical solutions based on the pseudo-steady state approximation are derived. The reliability and usefulness of the model are ascertained by comparison of the simulation results with matrix-type vaginal ring experimental release data reported in the literature. A good agreement between the model prediction and the experimental data is observed. An analysis of the effect of the variation… CONTINUE READING
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