Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer

@inproceedings{Lee2017MathematicalML,
  title={Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer},
  author={Mary Lee and George Tai-Jen Chen and Eric J. Puttock and Kehui Wang and R. A. Edwards and Marian L Waterman and John Lowengrub},
  booktitle={Molecular systems biology},
  year={2017}
}
Cell-intrinsic metabolic reprogramming is a hallmark of cancer that provides anabolic support to cell proliferation. How reprogramming influences tumor heterogeneity or drug sensitivities is not well understood. Here, we report a self-organizing spatial pattern of glycolysis in xenograft colon tumors where pyruvate dehydrogenase kinase (PDK1), a negative regulator of oxidative phosphorylation, is highly active in clusters of cells arranged in a spotted array. To understand this pattern, we… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 65 references

Some methods for strengthening the common v2 tests

  • WG Cochran
  • Biometrics 10:
  • 1954
Highly Influential
2 Excerpts

Multiscale modeling of glioma suggests that the partial disruption of vessel/cancer stem cell crosstalk can promote tumor regression without invasiveness

  • H Yan, M Romero-Lopez, CCW Hughes, JS Lowengrub
  • IEEE Trans Biomed Eng doi: 10.1109/TBME.2016…
  • 2016
1 Excerpt

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