Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer

  title={Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer},
  author={Mary Lee and George Tai-Jen Chen and Eric J. Puttock and Kehui Wang and R. A. Edwards and Marian L Waterman and John Lowengrub},
  booktitle={Molecular systems biology},
Cell-intrinsic metabolic reprogramming is a hallmark of cancer that provides anabolic support to cell proliferation. How reprogramming influences tumor heterogeneity or drug sensitivities is not well understood. Here, we report a self-organizing spatial pattern of glycolysis in xenograft colon tumors where pyruvate dehydrogenase kinase (PDK1), a negative regulator of oxidative phosphorylation, is highly active in clusters of cells arranged in a spotted array. To understand this pattern, we… CONTINUE READING
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