Mathematical model to predict coat weight variability in a pan coating process.

@article{Joglekar2007MathematicalMT,
  title={Mathematical model to predict coat weight variability in a pan coating process.},
  author={Anand Joglekar and Nitin S Joshi and Yongxin Song and James Ergun},
  journal={Pharmaceutical development and technology},
  year={2007},
  volume={12 3},
  pages={297-306}
}
The variability in drug release from extended-release products is strongly dependant on the tablet coat weight variability. A mechanistic model to predict the coefficient of variation (CV) of the tablet coat weight is proposed. Although the main assumption is complete random mixing, the model also assumes that each tablet spends a fixed amount of time in the coating zone and receives a fixed amount of coating in each coating event. The number of coating events that each tablet undergoes is… CONTINUE READING

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