Mathematical model of volume kinetics and renal function after burn injury and resuscitation.

  title={Mathematical model of volume kinetics and renal function after burn injury and resuscitation.},
  author={Ghazal Arabidarrehdor and Ali Tivay and Ramin Bighamian and Chris Meador and George C. Kramer and Jin-Oh Hahn and Jos{\'e} Salinas},
  journal={Burns : journal of the International Society for Burn Injuries},
This paper presents a mathematical model of blood volume kinetics and renal function in response to burn injury and resuscitation, which is applicable to the development and non-clinical testing of burn resuscitation protocols and algorithms. Prior mathematical models of burn injury and resuscitation are not ideally suited to such applications due to their limited credibility in predicting blood volume and urinary output observed in wide-ranging burn patients as well as in incorporating… 

Figures and Tables from this paper

Mathematical Modeling, In-Human Evaluation and Analysis of Volume Kinetics and Kidney Function After Burn Injury and Resuscitation
It is demonstrated that the mathematical model can replicate physiological responses in burn patients associated with wide demographic characteristics and injury severity, and that an increased inflammatory response to injury may be a key contributing factor in increasing the mortality risk of older patients and patients with inhalation injury via an increase in the fluid retention.
Inference-based subject atypicality and signal quality indicators for physiological data
Physiological measurements are an integral part of many established and emerging engineering and biomedical applications that involve physiological modeling, physiological state estimation, and


A model of fluid resuscitation following burn injury: formulation and parameter estimation.
A dynamic compartmental model is developed to describe the redistribution of fluid and albumin between the circulation and the intact and injured interstitia following burn injury in humans and is in reasonable agreement with the limited experimental data available from the literature.
Microvascular exchange during burn injury: II. Formulation and validation of a mathematical model.
A mathematical model of microvascular exchange in the rat following a burn injury was developed by extending an existing model of normal microvascular exchange to include perturbations characteristic
Microvascular exchange during burn injury: IV. Fluid resuscitation model.
The model and a statistical fitting procedure were used to find the ranges of fitting parameter values that best describe the changes in interstitial fluid volume and protein mass as well as transcapillary protein extravasation for three sets of experiments.
Modeling Fluid Resuscitation by Formulating Infusion Rate and Urine Output in Severe Thermal Burn Adult Patients: A Retrospective Cohort Study
The experimental results demonstrated that the developed dynamic fluid resuscitation model might significantly reduce the total fluid volume by accurately predicting hourly urine output and has the potential to aid fluid administration in severe burn patients.
Burn shock resuscitation
  • G. Warden
  • Medicine
    World Journal of Surgery
  • 2005
Improved statistics are derived from experience in burn centers, where there is substantial knowledge of the pathophysiology of burn injury and inadequate volume replacement in major burns is, unfortunately, common when clinicians lack sufficient knowledge in this area.
Glomerular filtration rate is increased in burn patients.
The clearance of iohexol (CL) was used to follow the glomerular filtration rate during the first week after burn and it is shown that CL values for burn patients were high.
Pathophysiology of burn shock and burn edema
Key circulatory factors that alter microvascular permeability, cause vasoconstriction, depolarize cellular membranes, and depress myocardial function need to be determined.
Fluid retention during the first 48 hours as an indicator of burn survival.
In this study of 82 adult burned patients with more than 20% total body surface burns it is found that the net fluid retention during the first 48 hours of resuscitation was a predictor of burn mortality and additionally 230 cc of retained fluid per kilogram of lean body mass in the initial 48 hours postburn was an excellent means for separating survivors from nonsurvivors.
A burn patient resuscitation therapy designed by computer simulation (BET). Part 1: Simulation studies.
This study presents an analysis of the fluid, electrolyte and colloid needs of burn patients during the shock phase using a burn patient simulator, which has been characterized by its effectiveness and minimal side-effects.
Analysis of burn injury by digital simulation.
A non-linear mathematical model for digital simulation of fluid distribution in burn patients during the first 48 h after injury is presented and the control mechanisms incorporated are adequate for describing the interactions between plasma and interstitial fluid and between the extra- and intracellular compartments.