Mathematical model for studying genetic variation in terms of restriction endonucleases.

@article{Nei1979MathematicalMF,
  title={Mathematical model for studying genetic variation in terms of restriction endonucleases.},
  author={Masatoshi Nei and Wen Li},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1979},
  volume={76 10},
  pages={5269-73}
}
A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotide substitutions between two populations or species. To express the degree of polymorphism in a population at the nucleotide level, a measure called "nucleotide diversity" is proposed. 
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