Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk.

@article{Jilkine2007MathematicalMF,
  title={Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk.},
  author={Alexandra Jilkine and Athanasius F. M. Mar{\'e}e and Leah Edelstein-Keshet},
  journal={Bulletin of mathematical biology},
  year={2007},
  volume={69 6},
  pages={
          1943-78
        }
}
Cdc42, Rac, and Rho are small GTPases known to play a central role in signal transduction to the actin cytoskeleton. These proteins regulate cell motility, by affecting nucleation, uncapping, and depolymerization of actin filaments, and acto-myosin contractility. Studies of crosstalk and mutual feedbacks in these three proteins have led to a number of proposals for their interaction. At the same time, observations of the spatio-temporal dynamics of Rho-family proteins give evidence of spatial… CONTINUE READING
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