Mathematical model for G-CSF administration after chemotherapy.

  title={Mathematical model for G-CSF administration after chemotherapy.},
  author={Catherine Foley and Michael C. Mackey},
  journal={Journal of theoretical biology},
  volume={257 1},
Granulocyte-colony stimulating factor (G-CSF) is used clinically for treating chemotherapy-induced neutropenia (low neutrophil levels). Here we present a delay differential equation model for the regulation of neutrophil production that accounts for the effects of G-CSF. Using a combination of analysis and numerical simulations, we use this model to study the effects of delaying G-CSF treatment following chemotherapy for two recombinant forms of G-CSF (filgrastim and pegfilgrastim). We also… CONTINUE READING


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