Mathematical investigation of IP3-dependent calcium dynamics in astrocytes

  title={Mathematical investigation of IP3-dependent calcium dynamics in astrocytes},
  author={Gregory Handy and M. Taheri and J. White and A. Borisyuk},
  journal={Journal of Computational Neuroscience},
  • Gregory Handy, M. Taheri, +1 author A. Borisyuk
  • Published 2017
  • Chemistry, Medicine, Computer Science
  • Journal of Computational Neuroscience
  • We study evoked calcium dynamics in astrocytes, a major cell type in the mammalian brain. Experimental evidence has shown that such dynamics are highly variable between different trials, cells, and cell subcompartments. Here we present a qualitative analysis of a recent mathematical model of astrocyte calcium responses. We show how the major response types are generated in the model as a result of the underlying bifurcation structure. By varying key channel parameters, mimicking blockers used… CONTINUE READING
    12 Citations
    Computational Models for Calcium-Mediated Astrocyte Functions
    • 28
    • Highly Influenced
    • PDF
    Spatiotemporal model of tripartite synapse with perinodal astrocytic process
    • 1
    Improved tools to study astrocytes
    • 17
    A mathematical model for interdependent calcium and inositol 1,4,5-trisphosphate in cardiac myocyte
    • N. Singh, N. Adlakha
    • Physics, Computer Science
    • Network Modeling Analysis in Health Informatics and Bioinformatics
    • 2019
    • 6
    Receptor recharge time drastically reduces the number of captured particles
    • 6
    • PDF
    27th Annual Computational Neuroscience Meeting (CNS*2018): Part One


    Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes
    • 127
    • Highly Influential
    • PDF
    A mathematical model of spontaneous calcium(II) oscillations in astrocytes.
    • 55
    • PDF
    Control and Plasticity of Intercellular Calcium Waves in Astrocytes: A Modeling Approach
    • 221
    • Highly Influential
    • PDF
    A Deterministic Model Predicts the Properties of Stochastic Calcium Oscillations in Airway Smooth Muscle Cells
    • 41
    • Highly Influential
    • PDF
    Probabilistic encoding of stimulus strength in astrocyte global calcium signals
    • 7
    • PDF
    Modeling the intracellular organization of calcium signaling
    • G. Dupont
    • Biology, Medicine
    • Wiley interdisciplinary reviews. Systems biology and medicine
    • 2014
    • 18
    Reading the patterns in living cells —the physics of ca2+ signaling
    • 307
    Control of calcium oscillations by membrane fluxes.
    • 123
    • PDF
    Long-lasting Changes of Calcium Oscillations in Astrocytes
    • 109
    • PDF
    Calcium signalling in astrocytes and modulation of neural activity
    • 53
    • PDF