Mathematical investigation of IP3-dependent calcium dynamics in astrocytes

@article{Handy2017MathematicalIO,
  title={Mathematical investigation of IP3-dependent calcium dynamics in astrocytes},
  author={Gregory Handy and M. Taheri and J. White and A. Borisyuk},
  journal={Journal of Computational Neuroscience},
  year={2017},
  volume={42},
  pages={257-273}
}
  • Gregory Handy, M. Taheri, +1 author A. Borisyuk
  • Published 2017
  • Chemistry, Medicine, Computer Science
  • Journal of Computational Neuroscience
  • We study evoked calcium dynamics in astrocytes, a major cell type in the mammalian brain. Experimental evidence has shown that such dynamics are highly variable between different trials, cells, and cell subcompartments. Here we present a qualitative analysis of a recent mathematical model of astrocyte calcium responses. We show how the major response types are generated in the model as a result of the underlying bifurcation structure. By varying key channel parameters, mimicking blockers used… CONTINUE READING
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